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Application progress of lymphography in oncology
Yang YU, Jibin LIU, Lixue YIN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 13-19 doi: 10.1007/s11684-009-0016-7
关键词: lymphography lymphatic metastasis sentinel lymph node biopsy
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 106-112 doi: 10.1007/s11684-014-0307-5
Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma (SCC) IA--IIA, and SCC IIB--IIIB (4.3%, 44%, and 88.9%, respectively). The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated β-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.
关键词: cervical cancer senescence Twist CBX3 lymph node metastasis
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 96-100 doi: 10.1007/s11684-014-0316-4
Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this study, 80 patients were divided into groups A and B. Group A consisted of 30 patients who underwent PAN+ pelvic lymph node (PLN) dissection, whereas group B consisted of 50 patients who only underwent PLN dissection. Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conducted. Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive for PAN, three cases for PLN, and nine cases for both PAN and PLN. In group B, 13 cases were positive for lymph node metastasis. Our study suggested that the metastatic rate of lymph node is 40.0%. Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological type both in groups A and B (P<0.05). In groups A and B, the three-year survival rates were 77.9% and 69.0%, and the five-year survival rates were 46.7% and 39.2%, respectively. However, the difference was not statistically significant (P>0.05). The three-year survival rates of PLN metastasis in groups A and B were 68.5% and 41.4%, and the five-year survival rates were 49.7% and 26.4%, respectively. Furthermore, PLN-positive patients who cleared PAN had significantly higher survival rate (P=0.044). In group A, the three-year survival rates of positive and negative lymph nodes were 43.5% and 72.7%, and the five-year survival rates were 27.2% and 58.5%, respectively. The difference was statistically significant (P=0.048). Cox model analysis of single factor suggested that lymph node status affected the survival rate (P<0.01), which was the death risk factor. Consequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, which has an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary.
关键词: ovarian cancer para-aortic lymph node pelvic lymph node
《医学前沿(英文)》 2023年 第17卷 第1期 页码 93-104 doi: 10.1007/s11684-021-0892-z
关键词: chemotherapy cervical cancer lymph node metastasis concurrent chemoradiotherapy quality of life
The value of ultrasound elastography in differential diagnosis of superficial lymph nodes
Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 368-374 doi: 10.1007/s11684-009-0063-0
关键词: ultrasound elastography lymph node power Doppler sonography
《医学前沿(英文)》 2022年 第16卷 第6期 页码 883-895 doi: 10.1007/s11684-022-0919-0
关键词: osteosarcoma autophagy metastasis drug resistance Beclin1 LC3B
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.
关键词: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic polymorphism
《医学前沿(英文)》 2022年 第16卷 第4期 页码 551-573 doi: 10.1007/s11684-022-0928-z
关键词: HCC bone osteotropism clinical basic researches advances
Spatial embedded reinforcement of 20-node block element for analysis PC bridges
LONG Peiheng, DU Xianting, CHEN Weizhen
《结构与土木工程前沿(英文)》 2008年 第2卷 第3期 页码 274-280 doi: 10.1007/s11709-008-0039-1
关键词: arithmetic analysis calculation prestressed reinforcement mechanical arbitrary
Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 443-446 doi: 10.1007/s11684-009-0079-5
Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen
《医学前沿(英文)》 2021年 第15卷 第4期 页码 621-628 doi: 10.1007/s11684-020-0738-0
关键词: early breast cancer 21-gene assay recurrence score prognosis
朱庄生,王庆,万德钧
《中国工程科学》 2009年 第11卷 第8期 页码 83-87
利用传统的基于节点连接的道路网络模型来表达真实世界中的道路网络,其存在的缺陷越来越突出,大大降低了导航系统的鲁棒性。为了消除这些缺陷,首次提出一个新的道路网络模型,即基于虚拟节点连接的道路网络模型,其虚拟节点是汇交路段的各个端点所围成的区域,具有真实道路路口的形状,与传统模型相比,该模型更能表达真实世界道路网络中的交通流,所以它能更好地满足地图匹配理论要求。另外,该模型能很好的表达真实道路路口参数,所以它在交通规划,交通管理和交通流模拟中都有着十分广阔的应用前景。
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 214-222 doi: 10.1007/s11684-017-0518-7
MicroRNAs (miRNAs) play critical roles in the development and progression in various cancers. Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarian cancer has been reached. In this study, results from the bioinformatics analysis show that the 3′-UTR of the E-cadherin mRNA was directly regulated by miR-9. Luciferase reporter assay results confirmed that miR-9 could directly target this 3′-UTR. miR-9 and E-cadherin expression in ovarian cancer tissue was quantified by qRT-PCR. Migration and invasion were detected by wound healing and Transwell system assay in SKOV3 and A2780. qRT-PCR and Western blot were performed to detect the epithelial?mesenchymal transition-associated mRNA and proteins. Immunofluorescence technique was used to analyze the expression and subcellular localization of E-cadherin, N-cadherin, and vimentin. The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue compared with paired primary ones. Upregulation of miR-9 could downregulate the expression of E-cadherin but upregulate the expression of mesenchymal markers (N-cadherin and vimentin). Overexpression of miR-9 could promote the cell migration and invasion in ovarian cancer, and these processes could be effectively inhibited via miR-9 inhibitor. Thus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherin and a novel potential therapeutic approach to control metastasis of ovarian cancer.
崔立群,伍军
《中国工程科学》 2020年 第22卷 第6期 页码 121-127 doi: 10.15302/J-SSCAE-2020.06.016
为了管理信息中心物联网(IC-IoT)不断变化的网络状态信息,本文针对信息中心物联网提出一种节点状态监测方案,以更好适应未来网络的发展。首先提出一种新的管理信息库结构用于记录各种网络节点状态信息,采用信息中心网络(ICN)的命名格式,以网络节点状态内容本身为中心。在此架构上采用跟踪路由方法,结合基于数据块重要性的自适应数据放置策略来获得所需的网络状态信息,提高网络节点状态信息检索效率,同时设计了安全防护机制来达到保证数据机密性与对管理用户进行访问控制的目的。搭建网络仿真测试环境评估了上述跟踪路由机制、自适应数据放置策略、访问控制安全防护带来的时延影响,仿真结果表明此方案能够有效地提高数据获取效率,访问控制模型提供了数据机密性和其他安全性功能,仅附加了少量的计算成本。
关键词: 信息中心网络,物联网,节点监测,访问控制
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Yun Zhang, Robert A. Weinberg
《医学前沿(英文)》 2018年 第12卷 第4期 页码 361-373 doi: 10.1007/s11684-018-0656-6
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axis. These cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and relapse. Currently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal phenotypic spectrum. An improved understanding of the dynamic and plastic nature of the EMT program has the potential to yield novel therapies targeting this cellular program that may aid in the management of high-grade malignancies.
关键词: epithelial-to-mesenchymal transition cancer metastasis cancer stem cell
标题 作者 时间 类型 操作
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical
null
期刊论文
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
null
期刊论文
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial
期刊论文
The value of ultrasound elastography in differential diagnosis of superficial lymph nodes
Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,
期刊论文
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance
期刊论文
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
期刊论文
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives
期刊论文
Spatial embedded reinforcement of 20-node block element for analysis PC bridges
LONG Peiheng, DU Xianting, CHEN Weizhen
期刊论文
Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its
Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,
期刊论文
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients
Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen
期刊论文
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
null
期刊论文